Possible roles for miRNAs during embryonic gonad development within the chicken

AMH sign transduction via the TGF-Я signalling path and involvement that is potential of.

AMH binds specifically towards the AMH receptor (AMHR2), which activates either activin receptor 1 (ACVR1), or bone tissue morphogenic receptor 1A (BMPR1A), or 1B (BMPR1B). Activated ACVR1 and BMPR1A transduce AMH signals by activating SMAD signalling proteins (SMAD1, 5 or 8), with the help of ZEB1. BMPR1B competitively antagonises SMAD activation. ZEB2 and TGIF bind to SMADs and SMAD DNA binding web sites, correspondingly, to inhibit signalling. MiR-101 ( red) is predicted to a target BMPR1B, ZEB1 and 2, and TGIF transcripts, and may also modulate signalling that is TGF-Я. miR-202-5p and miR-31 ( red) are predicted to focus on ACVR1 and SMAD5, and BMPR1A transcripts, correspondingly, that will assist a shifting TGF-Я signalling paths in men post-gonadal intercourse differentiation

Interestingly, miR-101 is predicted to focus on TGIF1, ZEB2 and BMPR1B (TargetScan, Lewis et al. 2005 ), which inhibit TGF-Я signalling.

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